Put the observed count of events in the top box and the expected count in the second box. The observed count should be an integer; the expected count can be real or integer. Give a covariance in the third box in case there is covariance between the observed and the expected. In that case you get an adjusted Fieller estimate of the confidence interval.
If Error in Expected is not checked the observed count is the only factor which determines the width of the Confidence Interval. The lower the count the wider the interval.
If Error in Expected is checked the width of the confidence interval is based on both the expected and the observed count. Use this option if you want to compare two Poisson counts from a similar domain. For example, if you want to compare events between different years or months to see if there is a difference between periods.
Check Use Observed Rate if you want a Confidence Interval around the observed rate only. With no error in expected the size of the expected count is irrelevant with regard to the width of this Confidence Interval.
Of the approximations the Log-Transformation considers error in the expected, all the other approximations use the error in the observed only.
This module was inspired by two papers, one by Liddell and one by Silcocks. The purpose of the procedure is to estimate the confidence interval for a rate ratio. In practice, this will often be the Standardized Mortality Ratio, the Standardised Morbidity Ratio (SMR) or the Comparative Mortality Figure (CMF). The rate ratio is most suited to study events in a constant domain while the denominator -i.e. the population at risk- is very large. For those who work with events in smaller samples this module is less interesting and the risk ratio or odds ratio will probably be more appropriate. The risk ratio and the odds ratio are implemented on the SISA website by the procedures t-test and two by two tables, and in the SISA-tables program.
In making comparisons, our instinct is to use subtraction. For example, in comparing the counts of pairs of breeding rare birds in different years, we tend to say that there are 20 more pairs this year than last year. It is a "good" year. The advantage of doing it this way is that it is easy to comprehend: it is easy to picture the pairs of breeding birds. The disadvantage is that it ignores the element of scale; 20 more pairs while the usual count is 500 is quite a different matter from having 20 more pairs while the usual count is 50. That is why we prefer to use ratios, or division. We take the count of birds we have observed this year and compare it with the count we had expected to observe on the grounds of previous experience. Thus, if we expected 500 breeding pairs, and have in fact observed 520 pairs this year, then we have an increase of 4%, 520/500=1.04 (*100). However, if we expected 50 breeding pairs, and have in fact observed 70 pairs, the increase is about 40%, 70/50=1.40. The next step is to use the generalizing statistical approach. This year, the count of breeding pairs of rare birds is 40% greater than the average in "ordinary" years, within a certain margin of confidence. The confidence interval given in the output gives you an impression of the precision of the estimate. If the value 1 (one) is not included in the confidence interval, the result is said to be statistically significant. There is a difference between the count of birds this year and last year, and the difference is not solely due to chance fluctuation.
The module presents various approximations for the confidence interval for the rate ratio. First, the exact confidence interval for the rate ratio by way of a Chi-square transformation of the Poisson is given. Liddell discusses this method. The way this is implemented results in an exact estimation of the Poisson confidence interval of about four significant digits precision. If the count of events exceeds 80, precision will decrease rapidly and it might be a better idea to use the Poisson process approximation, also discussed by Liddell. The program issues a warning when this seems advisable.
Silcocks has pointed out that an important assumption, namely that the expectation is theoretical and error free, is not valid when calculating the SMR in epidemiology and demography. The age specific rates in the standard population on which the calculation of the expectation is based are empirical observations, which will show random fluctuation. Also, in the breeding bird example, it is correct to use the Poisson to compare this years count of breeding birds with the "usual" count, a theoretical concept. However, it is not correct to make the same comparison between two years, using last year's observation as the expectation. Silcock proposes an exact procedure based on the Binomial/Incomplete Beta to estimate the confidence interval while taking into account that there may be an error in the expectation. Silcocks's ideas are implemented here, although technically the module works in a slightly different way. The procedure provides a binomial confidence interval around the rate ratio over a very large range of counts and with high precision.
Silcocks discusses in the same paper the use of the Fieller interval as an alternative to the Binomial method. The Fieller Confidence Interval has two applications: 1) The Fieller estimate is a method to estimate the approximate confidence interval around a rate ratio when there is error in both the observed and the expected value and the count of cases is relatively large. For very large counts, the Fieller provides a good method to approximate the results of the exact Binomial/Incomplete Beta method, which is also presented in the module. The Incomplete Beta method is the more suitable exact method for estimating the confidence interval around a rate ratio with error in both the observed and the expected values, but the method may not work well for a very large count of observations; 2) The Fieller method makes it possible to take covariance between the observation and the expectation into account. This would be relevant if the observations are a subset of the data on the basis of which the expectation was calculated. For example, the Standardised Mortality Ratio is often calculated by applying data of the national population to the local population. The mortality in Hampshire could be compared with the national mortality by using an expectation calculated by applying the national age-specific death rates (the standard) to the population of Hampshire (the index). A major crash on the motorway in Hampshire would show up in both the observation of the count of deaths in Hampshire and in the national death rates, which are used to calculate the expectation. Silcock (1994) proposes the covariance "q" parameter for the Fieller in such a case to be: q=Sum(d(i)*n(i)/N(i))/d-tot whereby, d(i) count of deaths in the index population in the i-th age band, n(i) count of individuals in the i-th age band of the index population which are part of the standard population, N(i) count of individuals in the i-th age band in the standard population, d-tot, total count of deaths in the index population. The q-covariance parameter is entered in the program in the right bottom "(Co-)Variance" box. The default setting of this parameter is zero. The Fieller will give an estimate only if the expected value is larger than one. Thus, real cases or a mean of real cases is considered and not a proportion.
Lastly: the Walds approximation (Rothman and Greenland, 1998); the square root (or Vandenbroucke), normal deviate and the Poisson process (or Byar)(Liddell, 1984); a logarithmic estimate and a suggestion by Pearson are presented.